Dendritic signals command firing dynamics in a mathematical model of cerebellar Purkinje cells.

Stéphane Genet 1 Loïc Sabarly 1 Emmanuel Guigon 1 Hugues Berry 2, 3 Bruno Delord 1
3 COMBINING - COMputational BIology and data miNING
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes
Abstract : Dendrites of cerebellar Purkinje cells (PCs) respond to brief excitations from parallel fibers with lasting plateau depolarizations. It is unknown whether these plateaus are local events that boost the synaptic signals or they propagate to the soma and directly take part in setting the cell firing dynamics. To address this issue, we analyzed a likely mechanism underlying plateaus in three representations of a reconstructed PC with increasing complexity. Analysis in an infinite cable suggests that Ca plateaus triggered by direct excitatory inputs from parallel fibers and their mirror signals, valleys (putatively triggered by the local feed forward inhibitory network), cannot propagate. However, simulations of the model in electrotonic equivalent cables prove that Ca plateaus (resp. valleys) are conducted over the entire cell with velocities typical of passive events once they are triggered by threshold synaptic inputs that turn the membrane current inward (resp. outward) over the whole cell surface. Bifurcation analysis of the model in equivalent cables, and simulations in a fully reconstructed PC both indicate that dendritic Ca plateaus and valleys, respectively, command epochs of firing and silencing of PCs.
Type de document :
Article dans une revue
Biophysical Journal, Biophysical Society, 2010, 99 (2), pp.427-36. 〈10.1016/j.bpj.2010.04.056〉
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https://hal.inria.fr/inria-00575654
Contributeur : Hugues Berry <>
Soumis le : jeudi 10 mars 2011 - 22:09:43
Dernière modification le : mardi 16 janvier 2018 - 16:26:52

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Stéphane Genet, Loïc Sabarly, Emmanuel Guigon, Hugues Berry, Bruno Delord. Dendritic signals command firing dynamics in a mathematical model of cerebellar Purkinje cells.. Biophysical Journal, Biophysical Society, 2010, 99 (2), pp.427-36. 〈10.1016/j.bpj.2010.04.056〉. 〈inria-00575654〉

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