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Theses

Three-dimensional Polarized Light Imaging: Towards Multiscale and Multimodal Analysis with Diffusion Magnetic Resonance Imaging

Abstract : Diffusion Magnetic Resonance Imaging (dMRI) is the only non-invasive and in-vivo imaging modality able to provide human brain structural connectivity information. This is done via an estimation of the fiber orientation distribution (FOD) of white matter and dMRI tractography. In this thesis, three-dimensional Polarized Light Imaging (3D-PLI) is in- vestigated and, thanks to its high spatial resolution, is presented as a complementary and potential technique for validation and guidance of dMRI fiber orientation estimates and tracking. The main goal of this work is, thus, to propose a strategy to close the resolution gap between dMRI and 3D-PLI and to investigate metrics for their quantitative comparison and, henceforth, to pave the way for multiscale and multimodal image analysis. Contributions in this thesis are manifold. First, we study the 3D-PLI fiber orientation and propose a method to disentangle the sign ambiguity of its inclination angle for an accurate determination of the 3D orientation. Second, we introduce an analytical and fast technique to compute the FOD from microscopic 3D-PLI orientation estimates to the meso- or macroscopic dimensions of dMRI. Third, we perform tractography at multiple scales from 3D-PLI human brain data to demonstrate the preservation of the fiber tracts architecture regardless of the decrease in resolution. Finally, we investigate how these obtained tractograms can be inspected using homology theory for a quantitative evaluation between them. Overall, we develop original and efficient dMRI and 3D-PLI methods, validate on both synthetic and human data and lay the foundations for multiscale and multimodal studies between dMRI and 3D-PLI.
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https://hal.inria.fr/tel-03078802
Contributor : Abib Alimi <>
Submitted on : Wednesday, December 16, 2020 - 8:23:17 PM
Last modification on : Friday, December 18, 2020 - 3:42:49 AM

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  • HAL Id : tel-03078802, version 1

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Abib Alimi. Three-dimensional Polarized Light Imaging: Towards Multiscale and Multimodal Analysis with Diffusion Magnetic Resonance Imaging. Medical Imaging. Inria Sophia Antipolis - Méditerranée, Université Côte d'Azur, 2020. English. ⟨tel-03078802⟩

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