Skip to Main content Skip to Navigation
Journal articles

Chemotherapy may be delivered based on an integrated view of tumour dynamics.

Benjamin Ribba 1 Benoit You 2 Michel Tod Pascal Girard B. Tranchand 3 V. Trillet-Lenoir G. Freyer 4
1 NUMED - Numerical Medicine
UMPA-ENSL - Unité de Mathématiques Pures et Appliquées, Inria Grenoble - Rhône-Alpes
2 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
3 EA3738 - Ciblage thérapeutique en Oncologie
4 Université de Lyon
Abstract : The aim here was to explore the potential of pharmacokinetic (PK)/pharmacodynamic (PD) and physiopathological parameters in explaining the primary effects of an anti-cancer treatment that targets cells in a specific cell cycle phase. The authors applied a theoretical multi-scale disease model of tumour growth that integrates cancer processes at the cellular and tissue scales. The mathematical model at the cell level relies on a dynamic description of cell cycle regulation while the model at the tissue level is based on fluid mechanics considerations. Simulations show that the number of target cells oscillates as the tumour grows after a first cycle of chemotherapy. Both treatment effect and tumour growth processes drive these oscillations. Nonetheless, results indicate that parameters related to physiopathological processes may have greater relevance than classical drug-related parameters in determining the efficacy of a chemotherapy treatment protocol. Physiopathological parameters, in particular those related to cell cycle regulation, may be integrated in PK/PD models aimed at optimising the delivery of phase-specific cytotoxic treatments.
Document type :
Journal articles
Complete list of metadata
https://hal.inria.fr/hal-00756359
Contributor : Benjamin Ribba Connect in order to contact the contributor
Submitted on : Thursday, November 22, 2012 - 7:25:52 PM
Last modification on : Wednesday, March 24, 2021 - 10:51:47 AM

Identifiers

Collections

HCL | CNRS | INRIA | ENS-LYON | CHLS | TDS-MACS | UNIV-LYON1 | UDL

Citation

Benjamin Ribba, Benoit You, Michel Tod, Pascal Girard, B. Tranchand, et al.. Chemotherapy may be delivered based on an integrated view of tumour dynamics.. IET Systems Biology, Institution of Engineering and Technology, 2009, 3 (3), pp.180-90. ⟨10.1049/iet-syb.2008.0104⟩. ⟨hal-00756359⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

333

 

Contact                    Legal Notice                    Personal Data