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Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions

Abstract : Glioblastoma multiforme (GBM) causes significant neurological morbidity and short survival times. Brain invasion by GBM is associated with poor prognosis. Recent clinical trials of bevacizumab in newly-diagnosed GBM found no beneficial effects on overall survival times; however, the baseline health-related quality of life and performance status were maintained longer in the bevacizumab group and the glucocorticoid requirement was lower. Here, we construct a clinical-scale model of GBM whose predictions uncover a new pattern of recurrence in 11/70 bevacizumab-treated patients. The findings support an exception to the Folkman hypothesis: GBM grows in the absence of angiogenesis by a cycle of proliferation and brain invasion that expands necrosis. Furthermore, necrosis is positively correlated with brain invasion in 26 newly-diagnosed GBM. The unintuitive results explain the unusual clinical effects of bevacizumab and suggest new hypotheses on the dynamic clinical effects of migration by active transport, a mechanism of hypoxia-driven brain invasion.
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https://hal.inria.fr/hal-01101651
Contributor : Olivier Saut <>
Submitted on : Friday, January 9, 2015 - 11:26:01 AM
Last modification on : Thursday, February 11, 2021 - 2:54:02 PM

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Elizabeth Scribner, Olivier Saut, Province Paula, Bag Asim, Thierry Colin, et al.. Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions. PLoS ONE, Public Library of Science, 2014, pp.21. ⟨10.1371/journal.pone.0115018⟩. ⟨hal-01101651⟩

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