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Patient-Specific Biomechanical Modeling of Cardiac Amyloidosis – A Case Study

Abstract : We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.
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https://hal.inria.fr/hal-01174913
Contributor : Dominique Chapelle <>
Submitted on : Friday, July 10, 2015 - 10:48:44 AM
Last modification on : Friday, April 30, 2021 - 9:57:18 AM
Long-term archiving on: : Monday, October 12, 2015 - 11:30:43 AM

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Dominique Chapelle, Alessandro Felder, Radomir Chabiniok, Aziz Guellich, Jean-François Deux, et al.. Patient-Specific Biomechanical Modeling of Cardiac Amyloidosis – A Case Study. Functional Imaging and Modeling of the Heart 2015, Jun 2015, Maastricht, Netherlands. pp.295-303, ⟨10.1007/978-3-319-20309-6_34⟩. ⟨hal-01174913⟩

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