Patient-Specific Biomechanical Modeling of Cardiac Amyloidosis – A Case Study

Abstract : We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.
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H. van Assen; P. Bovendeerd; T. Delhaas. Functional Imaging and Modeling of the Heart 2015, Jun 2015, Maastricht, Netherlands. Springer, 9126, pp.295-303, 2015, Lecture Notes in Computer Science. 〈10.1007/978-3-319-20309-6_34〉
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https://hal.inria.fr/hal-01174913
Contributeur : Dominique Chapelle <>
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Dernière modification le : jeudi 10 mai 2018 - 02:01:46
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Dominique Chapelle, Alessandro Felder, Radomir Chabiniok, Aziz Guellich, Jean-François Deux, et al.. Patient-Specific Biomechanical Modeling of Cardiac Amyloidosis – A Case Study. H. van Assen; P. Bovendeerd; T. Delhaas. Functional Imaging and Modeling of the Heart 2015, Jun 2015, Maastricht, Netherlands. Springer, 9126, pp.295-303, 2015, Lecture Notes in Computer Science. 〈10.1007/978-3-319-20309-6_34〉. 〈hal-01174913〉

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