Emergence of cytotoxic resistance in cancer cell populations: From individual-level mechanisms to population-level consequences

Tommaso Lorenzi 1 Rebecca H. Chisholm 2 Alexander Lorz 3, 4 Annette K Larsen 5 Luís Almeida 3, 4 Alexandre Escargueil 5 Jean Clairambault 3, 4
1 CMLA - Centre de Mathématiques et de Leurs Applications
2 UNSW - University of New South Wales [Sydney]
3 LJLL - Laboratoire Jacques-Louis Lions
4 MAMBA - Modelling and Analysis for Medical and Biological Applications
LJLL - Laboratoire Jacques-Louis Lions, Inria Paris-Rocquencourt
5 Cancerologie Fondamentale et Clinique des Tumeurs Solides
Abstract : We formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.
Document type :
Conference papers
Complete list of metadatas

Cited literature [15 references]  Display  Hide  Download
https://hal.inria.fr/hal-01249235
Contributor : Jean Clairambault <>
Submitted on : Monday, January 4, 2016 - 4:45:00 PM
Last modification on : Thursday, December 19, 2019 - 1:54:58 AM
Long-term archiving on: Thursday, April 7, 2016 - 4:48:22 PM

File

itmconf_mod2015_00009.pdf
Files produced by the author(s)

Identifiers

Collections

CNRS | INSMI | UPMC | LJLL | INRIA | TDS-MACS | ENS-CACHAN | UNIV-PARIS-SACLAY | SORBONNE-UNIVERSITE | UNIV-PARIS7 | USPC | SU-MEDECINE | SU-SCIENCES

Citation

Tommaso Lorenzi, Rebecca H. Chisholm, Alexander Lorz, Annette K Larsen, Luís Almeida, et al.. Emergence of cytotoxic resistance in cancer cell populations: From individual-level mechanisms to population-level consequences. Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, V. Volpert and J. Clairambault, Mar 2015, Paris, France. ⟨10.1051/itmconf/20150500009⟩. ⟨hal-01249235⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

715

Files downloads

300

 

 

Contact

archive-ouverte@inria.fr