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Emergence of cytotoxic resistance in cancer cell populations: From individual-level mechanisms to population-level consequences
Abstract : We formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.
Cited literature [15 references]
https://hal.inria.fr/hal-01249235
Contributor : Jean Clairambault <>
Submitted on : Monday, January 4, 2016 - 4:45:00 PM
Last modification on : Wednesday, December 9, 2020 - 3:10:52 PM
Long-term archiving on: : Thursday, April 7, 2016 - 4:48:22 PM
Contributor : Jean Clairambault <>
Submitted on : Monday, January 4, 2016 - 4:45:00 PM
Last modification on : Wednesday, December 9, 2020 - 3:10:52 PM
Long-term archiving on: : Thursday, April 7, 2016 - 4:48:22 PM
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itmconf_mod2015_00009.pdf
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