Emergence of cytotoxic resistance in cancer cell populations: From individual-level mechanisms to population-level consequences

Tommaso Lorenzi 1 Rebecca H. Chisholm 2 Alexander Lorz 3, 4 Annette K Larsen 5 Luís Neves de Almeida 3, 4 Alexandre Escargueil 5 Jean Clairambault 3, 4
1 CMLA - Centre de Mathématiques et de Leurs Applications
2 UNSW - University of New South Wales [Sydney]
3 LJLL - Laboratoire Jacques-Louis Lions
4 MAMBA - Modelling and Analysis for Medical and Biological Applications
LJLL - Laboratoire Jacques-Louis Lions, Inria Paris-Rocquencourt
5 Cancerologie Fondamentale et Clinique des Tumeurs Solides
Abstract : We formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.
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Communication dans un congrès
Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Mar 2015, Paris, France. ITM Web of Conferences 5, 〈http://www.itm-conferences.org/〉. 〈10.1051/itmconf/20150500009〉
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Tommaso Lorenzi, Rebecca H. Chisholm, Alexander Lorz, Annette K Larsen, Luís Neves de Almeida, et al.. Emergence of cytotoxic resistance in cancer cell populations: From individual-level mechanisms to population-level consequences. Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Mar 2015, Paris, France. ITM Web of Conferences 5, 〈http://www.itm-conferences.org/〉. 〈10.1051/itmconf/20150500009〉. 〈hal-01249235〉

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