This paper deals with the effect on life of the desynchronism between two variable amplitude load sequences in combined bending and torsion. Experiments were carried out on smooth specimens made of the EN-GJS800-2 cast iron. The comparison between experimental lives and predicted ones with the following fatigue life calculation methods is presented: Smith-Watson-Topper, Fatemi and Socie (method proposed by Bannantine), Wang and Brown, Socie's proposal for high cycle fatigue, and Morel. If the scatter of experiments is considered, these experiments show a low effect of the correlation factor on life. All the simulated fatigue life calculation methods give good results for proportional loads, but their predictions are not good for non-proportional loads. Morel’s proposal seems to be the best to predict life of the tested material with our non-proportional fatigue test conditions.