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A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

Dominik Glodzik 1 Sandro Morganella 1 Helen Davies 1 Peter T Simpson 2 Yilong Li 1 Xueqing Zou 1 Javier Diez-Perez 1 Johan Staaf 3 Ludmil B Alexandrov 4, 1 Marcel Smid 5 Arie B Brinkman 6 Inga Hansine Rye 7, 8 Hege Russnes 8, 7 Keiran Raine 1 Colin A Purdie 9 Sunil R Lakhani 2, 10 Alastair M Thompson 11, 12 Ewan Birney 13 Hendrik G Stunnenberg 5 Marc J van de Vijver 14 John W M Martens 5 Anne-Lise Børresen-Dale 8, 15 Andrea L Richardson 16, 17 Gu Kong 18 Alain Viari 19, 20 Douglas Easton 21 Gerard Evan 22 Peter J Campbell 1 Michael R Stratton 1 Serena Nik-Zainal 23, 1 
Abstract : Somatic rearrangements contribute to the mutagenized landscape of cancer genomes. Here, we systematically interrogated rearrangements in 560 breast cancers by using a piecewise constant fitting approach. We identified 33 hotspots of large (>100 kb) tandem duplications, a mutational signature associated with homologous-recombination-repair deficiency. Notably, these tandem-duplication hotspots were enriched in breast cancer germline susceptibility loci (odds ratio (OR) = 4.28) and breast-specific 'super-enhancer' regulatory elements (OR = 3.54). These hotspots may be sites of selective susceptibility to double-strand-break damage due to high transcriptional activity or, through incrementally increasing copy number, may be sites of secondary selective pressure. The transcriptomic consequences ranged from strong individual oncogene effects to weak but quantifiable multigene expression effects. We thus present a somatic-rearrangement mutational process affecting coding sequences and noncoding regulatory elements and contributing a continuum of driver consequences, from modest to strong effects, thereby supporting a polygenic model of cancer development.
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Submitted on : Friday, June 30, 2017 - 4:32:41 PM
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Dominik Glodzik, Sandro Morganella, Helen Davies, Peter T Simpson, Yilong Li, et al.. A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. Nature Genetics, 2017, 49 (3), pp.341 - 348. ⟨10.1038/ng.3771⟩. ⟨hal-01525728v2⟩



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