The Intensive Care Unit is a complex, data-intensive and critical environment in which the adoption of Information Technology is growing. As physicians become more dependent on the computing technology to support decisions, raise real-time alerts and notifications of patient-specific conditions, this software has strong dependability requirements. The dependability challenges are expressed in terms of availability, reliability, performance, usability and maintenance of the system. Our research focuses on the design and development of a generic autonomous ICU service platform. COSARA is a computer-based platform for infection surveillance and antibiotic management in ICU. During its design, development and evaluation, we identified both technological and human factors that affect robustness. We presented the identified research questions that will be addressed in detail during PhD research.