Modulation of spike-timing dependent plasticity: towards the inclusion of a third factor in computational models

Alexandre Foncelle 1, 2 Alexandre Mendes 3 Joanna Jedrzejewska-Szmek 4 Silvana Valtcheva 3 Hugues Berry 1, 2 Kim Blackwell 4 Laurent Venance 3
1 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive, CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
Abstract : In spike-timing dependent plasticity (STDP) change in synaptic strength depends on the timing of pre- versus postsynaptic spiking activity. Since STDP is in compliance with Hebb’s postulate, it is considered one of the major mechanisms of memory storage and recall. STDP comprises a system of two coincidence detectors with NMDA receptor activation often posited as one of the main components. Numerous studies have unveiled a third component of this coincidence detection system, namely neuromodulation and glia activity shaping STDP. Even though dopaminergic control of STDP has most often been reported, acetylcholine, noradrenaline, nitric oxide, BDNF or GABA also has been shown to effectively modulate STDP. Furthermore, it has been demonstrated that astrocytes, via the release or uptake of glutamate, gate STDP expression. At the most fundamental level, the timing properties of STDP are expected to depend on the spatiotemporal dynamics of the underlying signaling pathways. However in most cases, due to technical limitations experiments grant only indirect access to these pathways. Computational models carefully constrained by experiments, allow for a better qualitative understanding of the molecular basis of STDP and its regulation by neuromodulators. Recently, computational models of calcium dynamics and signaling pathway molecules have started to explore STDP emergence in ex and in vivo-like conditions. These models are expected to reproduce better at least part of the complex modulation of STDP as an emergent property of the underlying molecular pathways. Elucidation of the mechanisms underlying STDP modulation and its consequences on network dynamics is of critical importance and will allow better understanding of the major mechanisms of memory storage and recall both in health and disease.
Type de document :
Article dans une revue
Frontiers in Computational Neuroscience, Frontiers, 2018, 12, pp.49. 〈10.3389/fncom.2018.00049〉
Liste complète des métadonnées

Littérature citée [31 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01809075
Contributeur : Hugues Berry <>
Soumis le : mardi 3 juillet 2018 - 17:55:06
Dernière modification le : jeudi 1 novembre 2018 - 01:20:04
Document(s) archivé(s) le : lundi 1 octobre 2018 - 12:13:30

Fichier

Foncelle_2018_ReviewSTDP.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Alexandre Foncelle, Alexandre Mendes, Joanna Jedrzejewska-Szmek, Silvana Valtcheva, Hugues Berry, et al.. Modulation of spike-timing dependent plasticity: towards the inclusion of a third factor in computational models. Frontiers in Computational Neuroscience, Frontiers, 2018, 12, pp.49. 〈10.3389/fncom.2018.00049〉. 〈hal-01809075v2〉

Partager

Métriques

Consultations de la notice

242

Téléchargements de fichiers

64