Modulation of spike-timing dependent plasticity: towards the inclusion of a third factor in computational models

Abstract : In spike-timing dependent plasticity (STDP) change in synaptic strength depends on the timing of pre- versus postsynaptic spiking activity. Since STDP is in compliance with Hebb’s postulate, it is considered one of the major mechanisms of memory storage and recall. STDP comprises a system of two coincidence detectors with NMDA receptor activation often posited as one of the main components. Numerous studies have unveiled a third component of this coincidence detection system, namely neuromodulation and glia activity shaping STDP. Even though dopaminergic control of STDP has most often been reported, acetylcholine, noradrenaline, nitric oxide, BDNF or GABA also has been shown to effectively modulate STDP. Furthermore, it has been demonstrated that astrocytes, via the release or uptake of glutamate, gate STDP expression. At the most fundamental level, the timing properties of STDP are expected to depend on the spatiotemporal dynamics of the underlying signaling pathways. However in most cases, due to technical limitations experiments grant only indirect access to these pathways. Computational models carefully constrained by experiments, allow for a better qualitative understanding of the molecular basis of STDP and its regulation by neuromodulators. Recently, computational models of calcium dynamics and signaling pathway molecules have started to explore STDP emergence in ex and in vivo-like conditions. These models are expected to reproduce better at least part of the complex modulation of STDP as an emergent property of the underlying molecular pathways. Elucidation of the mechanisms underlying STDP modulation and its consequences on network dynamics is of critical importance and will allow better understanding of the major mechanisms of memory storage and recall both in health and disease.
Complete list of metadatas

Cited literature [169 references]  Display  Hide  Download

https://hal.inria.fr/hal-01809075
Contributor : Hugues Berry <>
Submitted on : Tuesday, July 3, 2018 - 5:55:06 PM
Last modification on : Thursday, November 21, 2019 - 2:03:03 AM
Long-term archiving on: Monday, October 1, 2018 - 12:13:30 PM

File

Foncelle_2018_ReviewSTDP.pdf
Files produced by the author(s)

Identifiers

Citation

Alexandre Foncelle, Alexandre Mendes, Joanna Jedrzejewska-Szmek, Silvana Valtcheva, Hugues Berry, et al.. Modulation of spike-timing dependent plasticity: towards the inclusion of a third factor in computational models. Frontiers in Computational Neuroscience, Frontiers, 2018, 12, pp.49. ⟨10.3389/fncom.2018.00049⟩. ⟨hal-01809075v2⟩

Share

Metrics

Record views

545

Files downloads

769