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Microscopic Simulation of the Cardiac Electrophysiology: A Study of the Influence of Different Gap Junctions Models
Abstract : It has been suggested in the literature that a disorgani-sation of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane , and the extracellular space are discretized individually [1]. We present in this article an improvement of this model, including gap junction models at any interface between cells. We then test this approach on hand-crafted two-dimensional networks of a hundred of cells, and compare it with our previous model which did not include gap junctions modelling.
Cited literature [6 references]
https://hal.inria.fr/hal-01910679
Contributor : Mark Potse <>
Submitted on : Thursday, November 1, 2018 - 5:37:43 PM
Last modification on : Saturday, May 18, 2019 - 9:38:03 PM
Document(s) archivé(s) le : Saturday, February 2, 2019 - 1:57:46 PM
Contributor : Mark Potse <>
Submitted on : Thursday, November 1, 2018 - 5:37:43 PM
Last modification on : Saturday, May 18, 2019 - 9:38:03 PM
Document(s) archivé(s) le : Saturday, February 2, 2019 - 1:57:46 PM
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