Abstract : It has been suggested in the literature that a disorgani-sation of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane , and the extracellular space are discretized individually [1]. We present in this article an improvement of this model, including gap junction models at any interface between cells. We then test this approach on hand-crafted two-dimensional networks of a hundred of cells, and compare it with our previous model which did not include gap junctions modelling.
https://hal.inria.fr/hal-01910679
Contributor : Mark Potse <>
Submitted on : Thursday, November 1, 2018 - 5:37:43 PM Last modification on : Saturday, May 18, 2019 - 9:38:03 PM Long-term archiving on: : Saturday, February 2, 2019 - 1:57:46 PM
Pierre-Elliott Bécue, Mark Potse, Yves Coudière. Microscopic Simulation of the Cardiac Electrophysiology: A Study of the Influence of Different Gap Junctions Models. Computing in Cardiology, Sep 2018, Maastricht, Netherlands. ⟨hal-01910679⟩