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Microscopic Simulation of the Cardiac Electrophysiology: A Study of the Influence of Different Gap Junctions Models

Pierre-Elliott Bécue 1, 2, 3 Mark Potse 1, 2, 3 Yves Coudière 1, 2, 3
2 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
IHU-LIRYC, IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest
Abstract : It has been suggested in the literature that a disorgani-sation of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane , and the extracellular space are discretized individually [1]. We present in this article an improvement of this model, including gap junction models at any interface between cells. We then test this approach on hand-crafted two-dimensional networks of a hundred of cells, and compare it with our previous model which did not include gap junctions modelling.
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Pierre-Elliott Bécue, Mark Potse, Yves Coudière. Microscopic Simulation of the Cardiac Electrophysiology: A Study of the Influence of Different Gap Junctions Models. Computing in Cardiology, Sep 2018, Maastricht, Netherlands. ⟨hal-01910679⟩

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