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Microscopic Simulation of the Cardiac Electrophysiology: A Study of the Influence of Different Gap Junctions Models

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Abstract

It has been suggested in the literature that a disorgani-sation of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane , and the extracellular space are discretized individually [1]. We present in this article an improvement of this model, including gap junction models at any interface between cells. We then test this approach on hand-crafted two-dimensional networks of a hundred of cells, and compare it with our previous model which did not include gap junctions modelling.
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Dates and versions

hal-01910679 , version 1 (01-11-2018)

Identifiers

  • HAL Id : hal-01910679 , version 1

Cite

Pierre-Elliott Bécue, Mark Potse, Yves Coudière. Microscopic Simulation of the Cardiac Electrophysiology: A Study of the Influence of Different Gap Junctions Models. Computing in Cardiology, Sep 2018, Maastricht, Netherlands. ⟨hal-01910679⟩
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