Skip to Main content Skip to Navigation
Journal articles

Stochastic analysis of emergence of evolutionary cyclic behavior in population dynamics with transfer

Abstract : Horizontal gene transfer consists in exchanging genetic materials between microorganisms during their lives. This is a major mechanism of bacterial evolution and is believed to be of main importance in antibiotics resistance. We consider a stochastic model for the evolution of a discrete population structured by a trait taking finitely many values, with density-dependent competition. Traits are vertically inherited unless a mutation occurs, and can also be horizontally transferred by unilateral conjugation with frequency dependent rate. Our goal is to analyze the trade-off between natural evolution to higher birth rates and transfer, which drives the population towards lower birth rates. Simulations show that evolutionary outcomes include evolutionary suicide or cyclic re-emergence of small populations with well-adapted traits. We focus on a parameter scaling where individual mutations are rare but the global mutation rate tends to infinity. This implies that negligible sub-populations may have a strong contribution to evolution. Our main result quantifies the asymptotic dynamics of subpopulation sizes on a logarithmic scale. We characterize the possible evolutionary outcomes with explicit criteria on the model parameters. An important ingredient for the proofs lies in comparisons of the stochastic population process with linear or logistic birth-death processes with immigration. For the latter processes, we derive several results of independent interest.
Complete list of metadata

https://hal.inria.fr/hal-01974289
Contributor : Nicolas Champagnat Connect in order to contact the contributor
Submitted on : Monday, February 1, 2021 - 4:58:25 PM
Last modification on : Friday, January 21, 2022 - 3:09:09 AM

File

Transfert-oaxaca-02-10-2020.pd...
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Nicolas Champagnat, Sylvie Méléard, Viet Chi Tran. Stochastic analysis of emergence of evolutionary cyclic behavior in population dynamics with transfer. Annals of Applied Probability, Institute of Mathematical Statistics (IMS), 2021, 31 (4), pp.1820-1867. ⟨10.1214/20-AAP1635⟩. ⟨hal-01974289v3⟩

Share

Metrics

Les métriques sont temporairement indisponibles