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Numerical modelling challenges for clinical electroporation ablation technique of liver tumors

Olivier Gallinato 1 Baudouin Denis de Senneville 1 Olivier Seror 2 Clair Poignard 1
1 MONC - Modélisation Mathématique pour l'Oncologie
IMB - Institut de Mathématiques de Bordeaux, Institut Bergonié [Bordeaux], Inria Bordeaux - Sud-Ouest
Abstract : Electroporation ablation is a promising non surgical and minimally invasive technique of tumor ablation, for which no monitoring is currently available. In this paper, we present the recent advances and challenges on the numerical modeling of clinical electroporation ablation of liver tumors. In particular, we show that a nonlinear static electrical model of tissue combined with clinical imaging can give crucial information of the electric field distribution in the clinical configuration. We conclude the paper by presenting some important questions that have to be addressed for an effective impact of computational modeling in clinical practice of electroporation ablation. Mathematics Subject Classification. 35J15, 35J87, 92B.
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Submitted on : Friday, February 28, 2020 - 10:48:18 AM
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Olivier Gallinato, Baudouin Denis de Senneville, Olivier Seror, Clair Poignard. Numerical modelling challenges for clinical electroporation ablation technique of liver tumors. Mathematical Modelling of Natural Phenomena, EDP Sciences, 2020, 15, ⟨10.1051/mmnp/2019037⟩. ⟨hal-02493795⟩

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