Effects of low dose radiation on atherosclerosis in APOE(-/-) mice: study of short term effects on macrophage polarization
Abstract
Athersoclerosis is a chronic inflammatory disease of medium and large arteries that can lead to myocardial infarction or stroke. Mechanistic understanding of the effects of low-dose ionizing radiation (LDIR) on atherosclerosis remains incomplete. The experimental studies have shown a protective effect of LDIR on atherosclerosis in rodent models. However early responses of LDIR in different cell types that are known to be involved in atherosclerosis is not clear. The objective is to understand biological mechanisms of LDIR include on animal groups with multimodal approach. In this study, we report results of applying the foldchange, usually considered a relevant criterion for stating difference and similarity between measurements and a multilevel multivariate approach. Revealing complex correlations and causal links related to health conditions, such as atherosclerosis, can help advance the concept adverse outcome pathway (AOP).
Domains
Life Sciences [q-bio]
Origin : Files produced by the author(s)
Licence : Copyright
Licence : Copyright