A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn’s Disease: A Population-based Study - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Inflammatory Bowel Diseases Year : 2023

A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn’s Disease: A Population-based Study

Hélène Sarter (1, 2) , Guillaume Savoye (3, 4, 5, 6) , Guillemette Marot (7, 8) , Delphine Ley (1, 2) , Dominique Turck (2) , Jean-Pierre Hugot , Francis Vasseur (7) , Alain Duhamel (7) , Pauline Wils (1, 2) , Fred Princen , Jean-Frédéric Colombel (9) , Corinne Gower-Rousseau (10, 2) , Mathurin Fumery (11, 12, 13) , A Baudet , P Bayart , B Bazin , A Bebahani , J Becqwort , S Bellati , V Benet , H Benali , C Benard , C Benguigui , E Ben Soussan , A Bental , I Berkelmans , J Bernet , K Bernou , C Bernou-Dron , P Bertot , N Bertiaux-Vandaële , V Bertrand , E Billoud , N Biron , B Bismuth , M Bleuet , F Blondel , V Blondin , M Bobula , P Bohon , V Bondjemah , E Boniface , D Bonkovski , P Bonnière , E Bonvarlet , P Bonvarlet , A Boruchowicz , R Bostvironnois , M Boualit , A Bouazza , B Bouche , C Boudaillez , C Bourgeaux , M Bourgeois , A Bourguet , A Bourienne , H Boutaleb , A Bouthors , J Branche , G Bray , F Brazier , P Breban , M Bridenne , H Brihier , L Bril , V Brung-Lefebvre , P Bulois , P Burgiere , J Butel , J Canva , V Canva-Delcambre , J Capron , F Cardot , S Carette , P Carpentier , E Cartier , J Cassar , M Cassagnou , J Castex , P Catala , S Cattan , S Catteau , B Caujolle , G Cayron , C Chandelier , M Chantre , J Charles , T Charneau , M Chavance-Thelu , A Cheny , D Chirita , A Choteau , J Claerbout , P Clergue , H Coevoet , G Cohen , R Collet , M Colin , J Colombel , S Coopman , L Cordiez , J Corvisart , A Cortot , F Couttenier , J Crinquette , V Crombe , I Dadamessi , H Daoudi , V Dapvril , T Davion , S Dautreme , J Debas , S Decoster , N Degrave , F Dehont , C Delatre , R Delcenserie , D Delesalle , O Delette , T Delgrange , L Delhoustal , J Delmotte , S Demmane , G Deregnaucourt , P Descombes , J Desechalliers , P Desmet , P Desreumaux , G Desseaux , P Desurmont , A Devienne , E Devouge , M Devred , A Devroux , A Dewailly , S Dharancy , A Di Fiore , D Djedir , R Djedir , W Doleh , M Dreher-Duwat , R Dubois , C Duburque , P Ducatillon , J Duclay , B Ducrocq , F Ducrot , P Ducrotte , A Dufilho , C Duhamel , D Dujardin , C Dumant-Forest , J Dupas , F Dupont , Y Duranton , A Duriez , N Duveau , K El Achkar , M El Farisi , C Elie , M Elie-Legrand , A Elkhaki , M Eoche , E Essmaeel , D Evrard , J Evrard , A Fatome , B Filoche , L Finet , M Flahaut , C Flamme , D Foissey , P Fournier , M Foutrein-Comes , P Foutrein , D Fremond , T Frere , P Gallais , C Gamblin , S Ganga , R Gerard , G Geslin , Y Gheyssens , N Ghossini , S Ghrib , T Gilbert , B Gillet , D Godart , P Godard , J Godchaux , R Godchaux , G Goegebeur , O Goria , F Gottrand , P Gower , B Grandmaison , M Groux , C Guedon , L Guerbeau , M Gueroult-Dero , J Guillard , L Guillem , F Guillemot , D Guimberd , B Haddouche , S Hakim , D Hanon , V Hautefeuille , P Heckestweiller , G Hecquet , J Hedde , H Hellal , P Henneresse , B Heyman , M Heraud , S Herve , P Hochain , L Houssin-Bailly , P Houcke , B Huguenin , S Iobagiu , S Istanboli , A Ivanovic , I Iwanicki-Caron , E Janicki , M Jarry , J Jeu , J Joly , C Jonas , A Jouvenet , F Katherin , A Kerleveo , A Khachfe , A Kiriakos , J Kiriakos , O Klein , M Kohut , R Kornhauser , D Koutsomanis , J Laberenne , E Lacotte , G Laffineur , M Lagarde , A Lalanne , A Lalieu , P Lannoy , J Lapchin , M Laprand , D Laude , R Leblanc , P Lecieux , S Lecleire , N Leclerc , C Le Couteulx , J Ledent , J Lefebvre , P Lefiliatre , C Le Goffic , C Legrand , A Le Grix , P Lelong , B Leluyer , C Lemaitre , C Lenaerts , G Lepeut , L Lepileur , A Leplat , E Lepoutre-Dujardin , H Leroi , M Leroy , P Le Roy , B Lesage , J Lesage , X Lesage , J Lesage , I Lescanne-Darchis , J Lescut , D Lescut , B Leurent , P Levy , M Lhermie , L Libier , A Lion , B Lisambert , I Loge , F Loire , J Loreau , S Louf , A Louvet , L Lubret , M Luciani , D Lucidarme , J Lugand , Eric N’guyen Khac (12, 14, 13)
Jean-Pierre Hugot
  • Function : Author
Fred Princen
  • Function : Author
A Baudet
  • Function : Author
P Bayart
  • Function : Author
B Bazin
  • Function : Author
A Bebahani
  • Function : Author
J Becqwort
  • Function : Author
S Bellati
  • Function : Author
V Benet
  • Function : Author
H Benali
  • Function : Author
C Benard
  • Function : Author
C Benguigui
  • Function : Author
E Ben Soussan
  • Function : Author
A Bental
  • Function : Author
I Berkelmans
  • Function : Author
J Bernet
  • Function : Author
K Bernou
  • Function : Author
C Bernou-Dron
  • Function : Author
P Bertot
  • Function : Author
N Bertiaux-Vandaële
  • Function : Author
V Bertrand
  • Function : Author
E Billoud
  • Function : Author
N Biron
  • Function : Author
B Bismuth
  • Function : Author
M Bleuet
  • Function : Author
F Blondel
  • Function : Author
V Blondin
  • Function : Author
M Bobula
  • Function : Author
P Bohon
  • Function : Author
V Bondjemah
  • Function : Author
E Boniface
  • Function : Author
D Bonkovski
  • Function : Author
P Bonnière
  • Function : Author
E Bonvarlet
  • Function : Author
P Bonvarlet
  • Function : Author
A Boruchowicz
  • Function : Author
R Bostvironnois
  • Function : Author
M Boualit
  • Function : Author
A Bouazza
  • Function : Author
B Bouche
  • Function : Author
C Boudaillez
  • Function : Author
C Bourgeaux
  • Function : Author
M Bourgeois
  • Function : Author
A Bourguet
  • Function : Author
A Bourienne
  • Function : Author
H Boutaleb
  • Function : Author
A Bouthors
  • Function : Author
J Branche
  • Function : Author
G Bray
  • Function : Author
F Brazier
  • Function : Author
  • PersonId : 1151134
  • IdRef : 060264497
P Breban
  • Function : Author
M Bridenne
  • Function : Author
H Brihier
  • Function : Author
L Bril
  • Function : Author
V Brung-Lefebvre
  • Function : Author
P Bulois
  • Function : Author
P Burgiere
  • Function : Author
J Butel
  • Function : Author
J Canva
  • Function : Author
V Canva-Delcambre
  • Function : Author
J Capron
  • Function : Author
F Cardot
  • Function : Author
S Carette
  • Function : Author
P Carpentier
  • Function : Author
E Cartier
  • Function : Author
J Cassar
  • Function : Author
M Cassagnou
  • Function : Author
J Castex
  • Function : Author
P Catala
  • Function : Author
S Cattan
  • Function : Author
S Catteau
  • Function : Author
B Caujolle
  • Function : Author
G Cayron
  • Function : Author
C Chandelier
  • Function : Author
M Chantre
  • Function : Author
J Charles
  • Function : Author
T Charneau
  • Function : Author
M Chavance-Thelu
  • Function : Author
A Cheny
  • Function : Author
D Chirita
  • Function : Author
A Choteau
  • Function : Author
J Claerbout
  • Function : Author
P Clergue
  • Function : Author
H Coevoet
  • Function : Author
G Cohen
  • Function : Author
R Collet
  • Function : Author
M Colin
  • Function : Author
J Colombel
  • Function : Author
S Coopman
  • Function : Author
L Cordiez
  • Function : Author
J Corvisart
  • Function : Author
A Cortot
  • Function : Author
F Couttenier
  • Function : Author
J Crinquette
  • Function : Author
V Crombe
  • Function : Author
I Dadamessi
  • Function : Author
H Daoudi
  • Function : Author
V Dapvril
  • Function : Author
T Davion
  • Function : Author
S Dautreme
  • Function : Author
J Debas
  • Function : Author
S Decoster
  • Function : Author
N Degrave
  • Function : Author
F Dehont
  • Function : Author
C Delatre
  • Function : Author
R Delcenserie
  • Function : Author
D Delesalle
  • Function : Author
O Delette
  • Function : Author
T Delgrange
  • Function : Author
L Delhoustal
  • Function : Author
J Delmotte
  • Function : Author
S Demmane
  • Function : Author
G Deregnaucourt
  • Function : Author
P Descombes
  • Function : Author
J Desechalliers
  • Function : Author
P Desmet
  • Function : Author
P Desreumaux
  • Function : Author
G Desseaux
  • Function : Author
P Desurmont
  • Function : Author
A Devienne
  • Function : Author
E Devouge
  • Function : Author
M Devred
  • Function : Author
A Devroux
  • Function : Author
A Dewailly
  • Function : Author
S Dharancy
  • Function : Author
A Di Fiore
  • Function : Author
D Djedir
  • Function : Author
R Djedir
  • Function : Author
W Doleh
  • Function : Author
M Dreher-Duwat
  • Function : Author
R Dubois
  • Function : Author
C Duburque
  • Function : Author
P Ducatillon
  • Function : Author
J Duclay
  • Function : Author
B Ducrocq
  • Function : Author
F Ducrot
  • Function : Author
P Ducrotte
  • Function : Author
A Dufilho
  • Function : Author
C Duhamel
  • Function : Author
D Dujardin
  • Function : Author
C Dumant-Forest
  • Function : Author
J Dupas
  • Function : Author
F Dupont
  • Function : Author
Y Duranton
  • Function : Author
A Duriez
  • Function : Author
N Duveau
  • Function : Author
K El Achkar
  • Function : Author
M El Farisi
  • Function : Author
C Elie
  • Function : Author
M Elie-Legrand
  • Function : Author
A Elkhaki
  • Function : Author
M Eoche
  • Function : Author
E Essmaeel
  • Function : Author
D Evrard
  • Function : Author
J Evrard
  • Function : Author
A Fatome
  • Function : Author
B Filoche
  • Function : Author
L Finet
  • Function : Author
M Flahaut
  • Function : Author
C Flamme
  • Function : Author
D Foissey
  • Function : Author
P Fournier
  • Function : Author
M Foutrein-Comes
  • Function : Author
P Foutrein
  • Function : Author
D Fremond
  • Function : Author
T Frere
  • Function : Author
P Gallais
  • Function : Author
C Gamblin
  • Function : Author
S Ganga
  • Function : Author
R Gerard
  • Function : Author
G Geslin
  • Function : Author
Y Gheyssens
  • Function : Author
N Ghossini
  • Function : Author
S Ghrib
  • Function : Author
T Gilbert
  • Function : Author
B Gillet
  • Function : Author
D Godart
  • Function : Author
P Godard
  • Function : Author
J Godchaux
  • Function : Author
R Godchaux
  • Function : Author
G Goegebeur
  • Function : Author
O Goria
  • Function : Author
F Gottrand
  • Function : Author
P Gower
  • Function : Author
B Grandmaison
  • Function : Author
M Groux
  • Function : Author
C Guedon
  • Function : Author
L Guerbeau
  • Function : Author
M Gueroult-Dero
  • Function : Author
J Guillard
  • Function : Author
L Guillem
  • Function : Author
F Guillemot
  • Function : Author
D Guimberd
  • Function : Author
B Haddouche
  • Function : Author
S Hakim
  • Function : Author
D Hanon
  • Function : Author
V Hautefeuille
  • Function : Author
P Heckestweiller
  • Function : Author
G Hecquet
  • Function : Author
J Hedde
  • Function : Author
H Hellal
  • Function : Author
P Henneresse
  • Function : Author
B Heyman
  • Function : Author
M Heraud
  • Function : Author
S Herve
  • Function : Author
P Hochain
  • Function : Author
L Houssin-Bailly
  • Function : Author
P Houcke
  • Function : Author
B Huguenin
  • Function : Author
S Iobagiu
  • Function : Author
S Istanboli
  • Function : Author
A Ivanovic
  • Function : Author
I Iwanicki-Caron
  • Function : Author
E Janicki
  • Function : Author
M Jarry
  • Function : Author
J Jeu
  • Function : Author
J Joly
  • Function : Author
C Jonas
  • Function : Author
A Jouvenet
  • Function : Author
F Katherin
  • Function : Author
A Kerleveo
  • Function : Author
A Khachfe
  • Function : Author
A Kiriakos
  • Function : Author
J Kiriakos
  • Function : Author
O Klein
  • Function : Author
M Kohut
  • Function : Author
R Kornhauser
  • Function : Author
D Koutsomanis
  • Function : Author
J Laberenne
  • Function : Author
E Lacotte
  • Function : Author
G Laffineur
  • Function : Author
M Lagarde
  • Function : Author
A Lalanne
  • Function : Author
A Lalieu
  • Function : Author
P Lannoy
  • Function : Author
J Lapchin
  • Function : Author
M Laprand
  • Function : Author
D Laude
  • Function : Author
R Leblanc
  • Function : Author
P Lecieux
  • Function : Author
S Lecleire
  • Function : Author
N Leclerc
  • Function : Author
C Le Couteulx
  • Function : Author
J Ledent
  • Function : Author
J Lefebvre
  • Function : Author
P Lefiliatre
  • Function : Author
C Le Goffic
  • Function : Author
C Legrand
  • Function : Author
A Le Grix
  • Function : Author
P Lelong
  • Function : Author
B Leluyer
  • Function : Author
C Lemaitre
  • Function : Author
C Lenaerts
  • Function : Author
G Lepeut
  • Function : Author
L Lepileur
  • Function : Author
A Leplat
  • Function : Author
E Lepoutre-Dujardin
  • Function : Author
H Leroi
  • Function : Author
M Leroy
  • Function : Author
P Le Roy
  • Function : Author
B Lesage
  • Function : Author
J Lesage
  • Function : Author
X Lesage
  • Function : Author
J Lesage
  • Function : Author
I Lescanne-Darchis
  • Function : Author
J Lescut
  • Function : Author
D Lescut
  • Function : Author
B Leurent
  • Function : Author
P Levy
  • Function : Author
M Lhermie
  • Function : Author
L Libier
  • Function : Author
A Lion
  • Function : Author
B Lisambert
  • Function : Author
I Loge
  • Function : Author
F Loire
  • Function : Author
J Loreau
  • Function : Author
S Louf
  • Function : Author
A Louvet
  • Function : Author
L Lubret
  • Function : Author
M Luciani
  • Function : Author
D Lucidarme
  • Function : Author
J Lugand
  • Function : Author

Abstract

Background The identification of patients at high risk of a disabling disease course would be invaluable in guiding initial therapy in Crohn’s disease (CD). Our objective was to evaluate a combination of clinical, serological, and genetic factors to predict complicated disease course in pediatric-onset CD. Methods Data for pediatric-onset CD patients, diagnosed before 17 years of age between 1988 and 2004 and followed more than 5 years, were extracted from the population-based EPIMAD registry. The main outcome was defined by the occurrence of complicated behavior (stricturing or penetrating) and/or intestinal resection within the 5 years following diagnosis. Lasso logistic regression models were used to build a predictive model based on clinical data at diagnosis, serological data (ASCA, pANCA, anti-OmpC, anti-Cbir1, anti-Fla2, anti-Flax), and 369 candidate single nucleotide polymorphisms. Results In total, 156 children with an inflammatory (B1) disease at diagnosis were included. Among them, 35% (n = 54) progressed to a complicated behavior or an intestinal resection within the 5 years following diagnosis. The best predictive model (PREDICT-EPIMAD) included the location at diagnosis, pANCA, and 6 single nucleotide polymorphisms. This model showed good discrimination and good calibration, with an area under the curve of 0.80 after correction for optimism bias (sensitivity, 79%, specificity, 74%, positive predictive value, 61%, negative predictive value, 87%). Decision curve analysis confirmed the clinical utility of the model. Conclusions A combination of clinical, serotypic, and genotypic variables can predict disease progression in this population-based pediatric-onset CD cohort. Independent validation is needed before it can be used in clinical practice.
No file

Dates and versions

hal-04124611 , version 1 (10-06-2023)

Identifiers

Cite

Hélène Sarter, Guillaume Savoye, Guillemette Marot, Delphine Ley, Dominique Turck, et al.. A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn’s Disease: A Population-based Study. Inflammatory Bowel Diseases, 2023, ⟨10.1093/ibd/izad090⟩. ⟨hal-04124611⟩
64 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More