Genomic loci influence patterns of structural covariance in the human brain
Junhao Wen
(1)
,
Ilya M Nasrallah
(2)
,
Ahmed Abdulkadir
(2)
,
Theodore D Satterthwaite
(2)
,
Zhijian Yang
(2)
,
Guray Erus
(2)
,
Timothy Robert-Fitzgerald
(2)
,
Ashish Singh
(2)
,
Aristeidis Sotiras
(3)
,
Aleix Boquet-Pujadas
(4)
,
Elizabeth Mamourian
(2)
,
Jimit Doshi
(2)
,
Yuhan Cui
(2)
,
Dhivya Srinivasan
(2)
,
Ioanna Skampardoni
(2)
,
Jiong Chen
(2)
,
Gyujoon Hwang
(2)
,
Mark Bergman
(2)
,
Jingxuan Bao
(2)
,
Yogasudha Veturi
(2)
,
Zhen Zhou
(2)
,
Shu Yang
(2)
,
Paola Dazzan
(5)
,
Rene S Kahn
(6)
,
Hugo G Schnack
(7)
,
Marcus V Zanetti
(8)
,
Eva Meisenzahl
(9)
,
Geraldo F Busatto
(8)
,
Benedicto Crespo-Facorro
(10)
,
Christos Pantelis
(11)
,
Stephen J Wood
(11)
,
Chuanjun Zhuo
(12)
,
Russell T Shinohara
(2)
,
Ruben C Gur
(2)
,
Raquel E Gur
(2)
,
Nikolaos Koutsouleris
(13)
,
Daniel H Wolf
(2)
,
Andrew J Saykin
(14)
,
Marylyn D Ritchie
(2)
,
Li Shen
(2)
,
Paul M Thompson
(1)
,
Olivier Colliot
(15)
,
Katharina Wittfeld
(16)
,
Hans J Grabe
(16)
,
Duygu Tosun
(17)
,
Murat Bilgel
(18)
,
Yang An
(18)
,
Daniel S Marcus
(3)
,
Pamela Lamontagne
(3)
,
Susan R Heckbert
(19)
,
Thomas R Austin
(19)
,
Lenore J Launer
(18)
,
Mark Espeland
(20)
,
Colin L Masters
(11)
,
Paul Maruff
(11)
,
Jurgen Fripp
(21)
,
Sterling C Johnson
(22)
,
John C Morris
(23)
,
Marilyn S Albert
(24)
,
R. Nick Bryan
(2)
,
Susan M Resnick
(18)
,
Yong Fan
(2)
,
Mohamad Habes
(25)
,
David Wolk
(2)
,
Haochang Shou
(2)
,
Christos Davatzikos
(2)
1
USC -
University of Southern California
2 University of Pennsylvania
3 Washington University School of Medicine [Saint Louis, MO]
4 EPFL - Ecole Polytechnique Fédérale de Lausanne
5 KCH - King's College Hospital
6 MSSM - Icahn School of Medicine at Mount Sinai [New York]
7 University Medical Center [Utrecht]
8 USP - Universidade de São Paulo = University of São Paulo
9 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
10 Universidad de Sevilla = University of Seville
11 University of Melbourne
12 Tianjin Medical University
13 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
14 Indiana State University
15 ARAMIS - Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris]
16 Universität Greifswald - University of Greifswald
17 UC San Francisco - University of California [San Francisco]
18 NIA - National Institute on Aging [Bethesda, USA]
19 University of Washington [Seattle]
20 Wake Forest School of Medicine [Winston-Salem]
21 The Australian e-Health Research centre
22 University of Wisconsin-Madison
23 WUSTL - Washington University in Saint Louis
24 Johns Hopkins University School of Medicine [Baltimore]
25 University of Texas Health Science Center
2 University of Pennsylvania
3 Washington University School of Medicine [Saint Louis, MO]
4 EPFL - Ecole Polytechnique Fédérale de Lausanne
5 KCH - King's College Hospital
6 MSSM - Icahn School of Medicine at Mount Sinai [New York]
7 University Medical Center [Utrecht]
8 USP - Universidade de São Paulo = University of São Paulo
9 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
10 Universidad de Sevilla = University of Seville
11 University of Melbourne
12 Tianjin Medical University
13 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
14 Indiana State University
15 ARAMIS - Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris]
16 Universität Greifswald - University of Greifswald
17 UC San Francisco - University of California [San Francisco]
18 NIA - National Institute on Aging [Bethesda, USA]
19 University of Washington [Seattle]
20 Wake Forest School of Medicine [Winston-Salem]
21 The Australian e-Health Research centre
22 University of Wisconsin-Madison
23 WUSTL - Washington University in Saint Louis
24 Johns Hopkins University School of Medicine [Baltimore]
25 University of Texas Health Science Center
Olivier Colliot
- Function : Author
- PersonId : 5286
- IdHAL : olivier-colliot
- ORCID : 0000-0002-9836-654X
- IdRef : 085263893
Abstract
Normal and pathologic neurobiological processes influence brain morphology in coordinated ways that give rise to patterns of structural covariance (PSC) across brain regions and individuals during brain aging and diseases. The genetic underpinnings of these patterns remain largely unknown. We apply a stochastic multivariate factorization method to a diverse population of 50,699 individuals (12 studies and 130 sites) and derive data-driven, multi-scale PSCs of regional brain size. PSCs were significantly correlated with 915 genomic loci in the discovery set, 617 of which are newly identified, and 72% were independently replicated. Key pathways influencing PSCs involve reelin signaling, apoptosis, neurogenesis, and appendage development, while pathways of breast cancer indicate potential interplays between brain metastasis and PSCs associated with neurodegeneration and dementia. Using support vector machines, multi-scale PSCs effectively derive imaging signatures of several brain diseases. Our results elucidate genetic and biological underpinnings that influence structural covariance patterns in the human brain.
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Origin : Files produced by the author(s)
Licence : CC BY - Attribution
Licence : CC BY - Attribution
Licence : CC BY - Attribution