Projects like SETI@home and Folding@home have popularized Internet Desktop Grid (IDG) computing. The first generation of IDG projects scalled to millions of participatings but was dedicated to a specific application. BOINC, United Device and XtremWeb belong to a second generation of IDG platforms. Their architecture was designed to accommodate many applications but has drawbacks like limited security and a centralized architecture. In this paper we present a new design for Internet Desktop Grid, following a layered approach. The new architecture establishes an overlay network, giving the participating nodes direct communication capabilities. From that basis many key mechanisms of IDG can be implemented using existing cluster tools and extra IDG specificic software. As a proof of concept, we run a bioinformatic application on a third generation IDG, based on a connectivity service (PVC), an existing job scheduler (Condor), a high performance data transport service (Bittorent) and a custom result certification mechanism.