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Journal articles
Anxiety in Mice: A Principal Component Analysis Study
Yan Clément
1
Chantal Joubert
2
Caroline Kopp
3
Eve M. Lepicard
2
Patrice Venault
2
René Misslin
3
Martine Cadot
4
Georges Chapouthier
2
4
PAROLE - Analysis, perception and recognition of speech
INRIA Lorraine, LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications
Patrice Venault 2
Author
René Misslin 3
Author
Martine Cadot 4
Mail :
Author Employer institution : Université Henri Poincaré - Nancy 1 IdHAL : martine-cadot
Georges Chapouthier 2
Author
1
MERC - Matrice extracellulaire et régulations cellulaires (Faculté de Médecine 51 Rue Cognacq-Jay 51095 REIMS CEDEX - France)
- URCA - Université de Reims Champagne-Ardenne (9 boulevard de la Paix - CS 60005 - 51724 Reims cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6198 (France)
2
VAP - Vulnérabilité Adaptation et Psychopathologie (Pavillon Clérambault Hôpital de la Salpétrière 47, BD de l'Hôpital 75651 PARIS 13 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7593 (France)
4
PAROLE - Analysis, perception and recognition of speech (France)
- INRIA Lorraine (615 rue du Jardin Botanique 54600 Villers-lès-Nancy - France)
- Inria - Institut National de Recherche en Informatique et en Automatique (Domaine de Voluceau Rocquencourt - BP 105 78153 Le Chesnay Cedex - France)
- LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications (Campus Scientifique BP 239 54506 Vandoeuvre-lès-Nancy Cedex - France)
- Inria - Institut National de Recherche en Informatique et en Automatique (Domaine de Voluceau Rocquencourt - BP 105 78153 Le Chesnay Cedex - France)
- UHP - Université Henri Poincaré - Nancy 1 (24-30 rue Lionnois, BP 60120, 54 003 NANCY cedex, France - France)
- Université Nancy 2 (91 avenue de la Libération, BP 454, 54001 Nancy cedex - France)
- INPL - Institut National Polytechnique de Lorraine (France)
- CNRS - Centre National de la Recherche Scientifique : UMR7503 (France)
Abstract : Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory paradigm and light-dark discrimination were used for the second. The components in the analyses produced definitions of four fundamental behavior patterns: novelty-induced anxiety, general activity, exploratory behavior, and decision making. We also noted that the anxious phenotype was determined by both strain and experimental procedure. The relationship between behavior patterns and the use of specific tests plus links with the genetic background are discussed.
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Journal articles
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https://hal.inria.fr/inria-00186107
Contributor : Martine Cadot <>
Submitted on : Wednesday, November 7, 2007 - 10:46:12 PM
Last modification on : Thursday, April 23, 2020 - 2:26:35 PM
Contributor : Martine Cadot <>
Submitted on : Wednesday, November 7, 2007 - 10:46:12 PM
Last modification on : Thursday, April 23, 2020 - 2:26:35 PM
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- HAL Id : inria-00186107, version 1
- DOI : 10.1155/2007/35457
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INRIA | CNRS | INSMI | UPMC | UNIV-PARIS7 | LORIA | USPC | UNIV-LORRAINE | URCA | SORBONNE-UNIVERSITE | SITE-ALSACE
Citation
Yan Clément, Chantal Joubert, Caroline Kopp, Eve M. Lepicard, Patrice Venault, et al.. Anxiety in Mice: A Principal Component Analysis Study. Neural plasticity, Hymie Anisman, 2007, ⟨10.1155/2007/35457⟩. ⟨inria-00186107⟩
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