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Anxiety in Mice: A Principal Component Analysis Study
Abstract : Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory paradigm and light-dark discrimination were used for the second. The components in the analyses produced definitions of four fundamental behavior patterns: novelty-induced anxiety, general activity, exploratory behavior, and decision making. We also noted that the anxious phenotype was determined by both strain and experimental procedure. The relationship between behavior patterns and the use of specific tests plus links with the genetic background are discussed.
https://hal.inria.fr/inria-00186107
Contributor : Martine Cadot Connect in order to contact the contributor
Submitted on : Wednesday, November 7, 2007 - 10:46:12 PM
Last modification on : Tuesday, November 16, 2021 - 4:55:40 AM
Contributor : Martine Cadot Connect in order to contact the contributor
Submitted on : Wednesday, November 7, 2007 - 10:46:12 PM
Last modification on : Tuesday, November 16, 2021 - 4:55:40 AM
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