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Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation

Abstract : The dynamics of the subthalamo-pallidal complex in Parkinson's disease (PD) during deep brain stimulation (DBS) are studied using two models, a simple firing-rate model and a population based model. We extend a simple firing-rate model of the complex formed by the subthalamic nucleus (STN) and the external segment of the Globus Pallidus (GPe) to explore its dynamical regime during DBS. More specifically, the modulation of neuronal activity (i.e., pattern and amplitude) during DBS is studied. A similar approach is used with a population based model. Simulation results reveal a progressive decrease of bursting activity in STN cells when DBS frequency is increased. In addition, the contribution of the stimulation current type (monophasic or biphasic) on the results is also examined. The two models provide qualitatively similar results, but the population based model is more biologically realistic and appears more appropriate to explore DBS mechanims. Understanding the underlying mechanisms of DBS is a prerequisite to the development of new stimulation protocols.
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https://hal.inria.fr/inria-00387802
Contributor : Jacques Henry <>
Submitted on : Monday, May 25, 2009 - 6:31:10 PM
Last modification on : Friday, March 15, 2019 - 9:06:01 AM

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J. Modolo, Jacques Henry, Anne Beuter. Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation. Journal of Biological Physics, Springer Verlag, 2008, 34 (3-4), pp.351-366. ⟨10.1007/s10867-008-9095-y⟩. ⟨inria-00387802⟩

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