Model-based Predictions of the Influence of Circadian Clock Genes Knock-Outs on the Cell Cycle

Elisabetta de Maria 1, * Francois Fages 1 Sylvain Soliman 1
* Corresponding author
1 CONTRAINTES - Constraint programming
Inria Paris-Rocquencourt
Abstract : The existence of links between the cell division cycle and the circadian clock has been recently discovered. In this research report, we perform a small in silico analysis of how mutations on the clock genes composing the mammalian circadian clock affect the phenotype of the cell cycle. For this purpose, we use a coupled model of the mammalian circadian clock and the mammalian cell cycle where the latter one is entrained by the former one via a common protein kinase WEE1. Our in silico experiments exploit the modeling environment BIOCHAM.
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Elisabetta de Maria, Francois Fages, Sylvain Soliman. Model-based Predictions of the Influence of Circadian Clock Genes Knock-Outs on the Cell Cycle. [Research Report] RR-7064, INRIA. 2009. ⟨inria-00424950v2⟩

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