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OPTIMAL PLACEMENT OF ELECTRODES IN AN ELECTROPORATION PROCESS

Abstract : Electroporation consists in increasing the permeability of a tissue by applying high voltage pulses. In this paper we discuss the question of optimal placement and optimal loading of electrodes such that electroporation holds only in a given open set of the domain. The electroporated set of the domain is where the norm of the electric field is above a given threshold value. We use a standard gradient algorithm to optimize the loading of the electrodes and shape sensitivity analysis and a gradient algorithm in order to move the electrodes. We also discuss the choice of objective functions to be chosen in the gradient algorithm.
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https://hal.inria.fr/inria-00544874
Contributor : Clair Poignard <>
Submitted on : Thursday, December 9, 2010 - 10:41:36 AM
Last modification on : Wednesday, June 9, 2021 - 1:08:03 PM

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Nicolae Cindea, Benoît Fabrèges, Frédéric de Gournay, Clair Poignard. OPTIMAL PLACEMENT OF ELECTRODES IN AN ELECTROPORATION PROCESS. ESAIM: Proceedings, EDP Sciences, 2010, 30, pp.34-43. ⟨10.1051/proc/2010004⟩. ⟨inria-00544874⟩

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