Measurement of total pulmonary arterial compliance using invasive pressure monitoring and MR flow quantification during MR-guided cardiac catheterization
Abstract : Pulmonary hypertensive disease is assessed by quantification of pulmonary vascular resistance. Pulmonary total arterial compliance is also an indicator of pulmonary hypertensive disease. However, because of difficulties in measuring compliance, it is rarely used. We describe a method of measuring pulmonary arterial compliance utilizing magnetic resonance (MR) flow data and invasive pressure measurements. Seventeen patients with suspected pulmonary hypertension or congenital heart disease requiring preoperative assessment underwent MR-guided cardiac catheterization. Invasive manometry was used to measure pulmonary arterial pressure, and phase-contrast MR was used to measure flow at baseline and at 20 ppm nitric oxide (NO). Total arterial compliance was calculated using the pulse pressure method (parameter optimization of the 2-element windkessel model) and the ratio of stroke volume to pulse pressure. There was good agreement between the two estimates of compliance (r = 0.98, P 10% in response to 20 ppm NO. As a population, the increase did not reach statistical significance. There was an inverse relation between compliance and resistance (r = 0.89, P < 0.001) and between compliance and mean pulmonary arterial pressure (r = 0.72, P < 0.001). We have demonstrated the feasibility of quantifying total arterial compliance using an MR method.
Type de document :
Article dans une revue
AJP - Heart and Circulatory Physiology, American Physiological Society, 2005, 289 (3), pp.1301-1306. 〈10.1152/ajpheart.00957.2004〉
https://hal.inria.fr/inria-00615658
Contributeur : Project-Team Asclepios
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Soumis le : vendredi 19 août 2011 - 18:06:29
Dernière modification le : mercredi 30 mai 2018 - 13:56:03
V. Muthurangu, D. Atkinson, Maxime Sermesant, M.E. Miquel, S. Hegde, et al.. Measurement of total pulmonary arterial compliance using invasive pressure monitoring and MR flow quantification during MR-guided cardiac catheterization. AJP - Heart and Circulatory Physiology, American Physiological Society, 2005, 289 (3), pp.1301-1306. 〈10.1152/ajpheart.00957.2004〉. 〈inria-00615658〉
