Influence of Transmural Slow-Conduction Zones on the Long- Time Behaviour Of Atrial Arrhythmia. A Numerical Study with a Human Bilayer Atrial Model

Abstract : Atrial fibrosis is known to be a factor in the perpetu ation of atrial arrhythmia. Despite the thinness of atrial tissue, the fibrosis distribution may not be homogeneous through the entire thickness of the atria. This study aims to elucidate the respective influences of a transmural and a non-transmural distribution of fibrosis, described as a slow conduction zone, on the perpetuation of an arrhythmic episode, compared to a control situation. We used a bilayer monodomain representation of the atria that included transmural heterogeneities of fibre organisation. This model allowed long simulations for a sustainable computational load. We observed that when the fibrosis was transmural, the centre of the rotor was anchored in the slow conduction zone and was stable during a 10 seconds simulation, whereas the other simulations showed meandering rotors that disappeared after a few seconds. This study provided insight into the influence of transmural fibrosis on atrial arrhythmia perpetuation. In our model framework, only a transmural fibrosis distribution had a stabilizing effect on reentrant circuits. The bilayer model proved to be a good trade-off between accuracy and speed for observing the influence of transmural heterogeneities on atrial arrhythmia over long periods.
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Communication dans un congrès
CINC - Computing in Cardiology 2013, Sep 2013, Zaragoza, Spain. 40, pp.1187-1190, 2013, Computing in Cardiology 2013,. 〈http://www.cinc.org/archives/2013/pdf/1187.pdf〉
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Simon Labarthe, Edward Vigmond, Yves Coudière, Jacques Henry, Hubert Cochet, et al.. Influence of Transmural Slow-Conduction Zones on the Long- Time Behaviour Of Atrial Arrhythmia. A Numerical Study with a Human Bilayer Atrial Model. CINC - Computing in Cardiology 2013, Sep 2013, Zaragoza, Spain. 40, pp.1187-1190, 2013, Computing in Cardiology 2013,. 〈http://www.cinc.org/archives/2013/pdf/1187.pdf〉. 〈hal-00921262〉

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