An introduction to modelling flower primordium initiation

Christophe Godin 1 Eugenio Azpeitia 1 Etienne Farcot 2
1 VIRTUAL PLANTS - Modeling plant morphogenesis at different scales, from genes to phenotype
CRISAM - Inria Sophia Antipolis - Méditerranée , INRA - Institut National de la Recherche Agronomique, Centre de coopération internationale en recherche agronomique pour le développement [CIRAD] : UMR51
Abstract : In this chapter we present models of processes involved in the initiation and development of a flower. In the first section, we briefly present models of hormonal transport. We focus on two key aspects of flower development, namely the initiation, due to the periodic local accumulation of auxin (a plant hormone) near at the plant apex, and the genetic regulation of its development. In the first section, we described the main assumptions about auxin transport that have been proposed and tested in the literature. We show how the use of models make it possible to test assumptions expressed in terms of local cell-to-cell interaction rules and to check if they lead to patterning in the growing tissue consistent with observation. Then, we investigated gene regulatory networks that controls the initial steps of flower development and differentiation. In a simplified form, this network contains a dozen of actors interacting with each other in space and time. The understanding of such a complex system here also requires a modeling approach in order to quantify these interactions and analyze their properties. We briefly present the two main formalisms that are used to model GRN: the Boolean and the ODE formalisms. We illustrate on a sub-module of the flower GRN both types of models and discuss their main advantages and drawbacks. We show how manipulations of the network models can be used to make predictions corresponding to possible biological manipulations of the GRN (e.g. loss-of-function mutants). Throughout the chapter, we highlight specific mathematical topics of particular interest to the development of the ideas developed in the different sections in separated boxes (called Math-boxes). The reading of these boxes is relatively independent of the main text.
Type de document :
Chapitre d'ouvrage
From Molecules to Living Organisms: An Interplay Between Biology and Physics, 102, 2015, Lecture Notes of the Les Houches School of Physics
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Soumis le : mardi 12 janvier 2016 - 17:32:07
Dernière modification le : samedi 27 janvier 2018 - 01:31:37
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  • HAL Id : hal-01254880, version 1



Christophe Godin, Eugenio Azpeitia, Etienne Farcot. An introduction to modelling flower primordium initiation. From Molecules to Living Organisms: An Interplay Between Biology and Physics, 102, 2015, Lecture Notes of the Les Houches School of Physics. 〈hal-01254880〉



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