Modelling of migration and orientation of endothelial cells on micropatterned polymers

Abstract : Understanding the cell migration on micropatterned polymers, as well as their orientation is a critical issue in tissue engineering, since it is the preliminary step in the blood vessel formation. In this paper, we derive an agent-based model to describe the migration and the orientation of endothelial cells seeded on bioactive micropatterned polymers. The model is obtained thanks to the experimental observations, and it provides numerical results that are quantitatively in accordance with the experimental data.