The Regression Conditional Tail Moment (RCTM) is the risk measure defined as the moment of order b ≥ 0 of a loss distribution above the upper α-quantile where α ∈ (0, 1) and when a covariate information is available. The purpose of this work is first to establish the asymptotic properties of the RCTM in case of extreme losses, i.e when α → 0 is no longer fixed, under general extreme-value conditions on their distribution tail. In particular, no assumption is made on the sign of the associated extreme-value index. Second, the asymptotic normality of a kernel estimator of the RCTM is established, which allows to derive similar results for estimators of related risk measures such as the Regression Conditional Tail Expec-tation/Variance/Skewness. When the distribution tail is upper bounded, an application to frontier estimation is also proposed. The results are illustrated both on simulated data and on a real dataset in the field of nuclear reactors reliability.